![]() ![]() VPS34 K29/K48 branched ubiquitination governed by UBE3C and TRABID regulates autophagy, proteostasis and liver metabolism. Yu-Hsuan Chen, Tzu-Yu Huang, Yu-Tung Lin, Shu-Yu Lin, Wen-Hsin Li, Hsiang-Jung Hsiao, Ruei-Liang Yan, Hong-Wen Tang, Zhao-Qing Shen, Guang-Chao Chen, Kuen-Phon Wu, Ting-Fen Tsai, Ruey-Hwa Chen. Endonuclease G promotes autophagy by suppressing mTOR signaling and activating the DNA damage response. Wenjun Wang, Jianshuang Li, Junyang Tan, Miaomiao Wang, Jing Yang, Zhi-Min Zhang, Chuanzhou Li, Alexei G Basnakian, Hong-Wen Tang, Norbert Perrimon, Qinghua Zhou. A Drosophila model of oral peptide therapeutics for adult Intestinal Stem Cell tumors. Anjali Bajpai, Quazi Taushif Ahmad, Hong-Wen Tang, Nishat Manzar, Virender Singh, Ashwani Thakur, Bushra Ateeq, Norbert Perrimon, Pradip Sinha. Cell Discovery volume 6, Article number: 44 (2020)ġ3. CG14906 (mettl4) mediates m6A methylation of U2 snRNA in Drosophila. Lei Gu, Longfei Wang, Hao Chen, Jiaxu Hong, Zhangfei Shen, Abhinav Dhall, Taotao Lao, Chaozhong Liu, Zheng Wang, Yifan Xu, Hong-Wen Tang, Damayanti Chakraborty, Jiekai Chen, Zhihua Liu, Dragana Rogulja, Norbert Perrimon, Hao Wu, Yang Shi. Proceedings of the National Academy of Sciences. An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity. Bosch, Christians Villalta, Xi He, and Norbert Perrimon. Chiwei Xu, Brian Franklin, Hong-Wen Tang, Yannik Regimbald-Dumas, Yanhui Hu, Justine Ramos, Justin A. Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation. Wei Song, Serkan Kir, Shangyu Hong, Yanhui Hu, Xiaohui Wang, Richard Binari, Hong-Wen Tang, Verena Chung, Alexander S Banks, Bruce Spiegelman, Norbert Perrimon. The Septate Junction Protein Tsp2A Restricts Intestinal Stem Cell Activity via Endocytic Regulation of aPKC and Hippo Signaling. Chiwei Xu, Hong-Wen Tang, Ruei-Jiun Hung, Yanhui Hu, Xiaochun Ni, Benjamin E Housden, Norbert Perrimon. The TORC1-regulated CPA complex rewires an RNA processing network to drive autophagy and metabolic reprogramming. Hong-Wen Tang# (Co-corresponding author), Yanhui Hu, Chiao-Lin Chen, Baolong Xia, Jonathan Zirin, Min Yuan, John M Asara, Leonard Rabinow, Norbert Perrimon. Xio is a component of the Drosophila sex determination pathway and RNA N6-methyladenosine methyltransferase complex. Jian Guo, Hong-Wen Tang, Jing Li, Norbert Perrimon, Dong Yan. Atg9 interacts with dTRAF2/TRAF6 to regulate oxidative stress-induced JNK activation and autophagy induction.ħ. Hong-Wen Tang, Hsiao-Man Liao, Wen-Hsin Peng, Hong-Ru Lin, Chun-Hong Chen, Guang-Chao Chen. Evaluation of Drosophila Metabolic Labeling Strategies for in Vivo Quantitative Proteomic Analyses with Applications to Early Pupa Formation and Amino Acid Starvation. Ying-Che Chang, Hong-Wen Tang, Suh-Yuen Liang, Tsung-Hsien Pu, Tzu-Ching Meng, Kay-Hooi Khoo, Guang-Chao Chen. Autophagy-related gene 7 is downstream of heat shock protein 27 in the regulation of eye morphology, polyglutamine toxicity, and lifespan in Drosophila. Shih-Fen Chen, Ming-Lun Kang, Yi-Chun Chen, Hong-Wen Tang (co-first author), Cheng-Wen Huang, Wan-Hua Li, Chun-Pu Lin, Chao-Yung Wang, Pei-Yu Wang, Guang-Chao Chen, Horng-Dar Wang. ![]() ![]() Unraveling the role of myosin in forming autophagosomes. Atg1‐mediated myosin II activation regulates autophagosome formation during starvation‐induced autophagy. Hong‐Wen Tang, Yu‐Bao Wang, Shiu‐Lan Wang, Mei‐Hsuan Wu, Shu‐Yu Lin, Guang‐Chao Chen. Genetic interactions between Drosophila melanogaster Atg1 and paxillin reveal a role for paxillin in autophagosome formation. Guang-Chao Chen, Janice Y Lee, Hong-Wen Tang, Jayanta Debnath, Sheila M Thomas, Jeffrey Settleman. Characterizing the impact of aging and cancer cachexia on stem cell self-renewal and differentiationġ.Exploring the role of autophagy during aging and tumorigenesis.Regulation of transcriptome and RNA epitranscriptome during aging.Regulation of transcriptome and RNA epitranscriptome by oncogenic signaling networks.His lab aims to contribute insights towards the biology of aging as well as tumorigenesis, and provide new therapeutic strategies targeting cancer and mitigating the effects of aging. His lab utilizes unique cross-species approach using the Drosophila, mouse and mammalian cells as model systems, coupled with interdisciplinary approach incorporating genetics, biochemistry, cell biology and systems biology, to identify new evolutionary conserved mechanisms underlying human diseases. The checker found no problems in this document.Dr Tang’s lab scientific focus is to understand how signaling networks rewire RNA metabolism to alter physiological functions during the process of aging and tumorigenesis. Acrobat Accessibility Report Accessibility Report Filename: 20101118_g.pdf Report created by: Organization: ![]()
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